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Y-90 Radioembolization

For the treatment of primary and metastatic liver tumors

Y-90 radioembolization (also called transarterial radioembolization or TARE) is a localized treatment for liver tumors that combines radiation therapy with embolization (blocking blood flow to the tumor). Instead of “systemic” treatment that exposes healthy tissue to radiation, Y-90 precisely targets liver cancer by cutting the tumor’s blood supply while simultaneously delivering radiation. Healthy tissue is spared, helping to preserve liver function.

Y-90 stands for yttrium-90, a radioactive isotope with a half-life of just 64.1 hours. The short half-life is ideal because it allows for an intense, highly concentrated dose of radiation to be delivered to the tumor without leaving a lingering radiation risk in the body.

Y-90 Radioembolization

Y-90 radioembolization is recommended for patients who are not eligible for liver resection surgery. It can also be used as a “bridge” treatment for those who need a liver transplant. Y-90 can slow the progression of liver cancer, relieve symptoms and help improve overall quality of life. It may also be used in combination with immunotherapy or chemotherapy.

This treatment is performed by an interventional radiologist using imaging to guide the procedure. A tiny catheter is inserted into an artery in the arm or leg, then advanced through the bloodstream to the hepatic artery. Once there, tiny microparticles containing yttrium-90 are injected into the arteries feeding the tumor. They become lodged in the smaller vessels and release their radiation into the tumor.

Y-90 treatment typically lasts for about an hour, and you can return home shortly after your treatment. Side effects include fatigue, fever, nausea and vomiting.

How does Y-90 radioembolization compare to other radiation therapies?

Healthy liver tissue is sensitive to radiation injury. Y-90 is different from other radiation therapies because it delivers radiation from inside the blood vessels that feed the tumor, instead of from outside the body. By more precisely targeting the tumor and not exposing healthy tissue to radiation, Y-90 radioembolization can help preserve liver tissue and liver function.

For more information, or to schedule a consultation with one of our doctors, please visit our contact page or call (720) 516-0637.